(often used with the, sometimes capitalized: the Plague) The bubonic plague, the pestilent disease caused by the virulent bacterium Yersinia pestis.

(pathology) An epidemic or pandemic caused by any pestilence, but specifically by the above disease.

A widespread affliction, calamity or destructive influx, especially when seen as divine retribution.

(figurative) A grave nuisance, whatever greatly irritates.

(ornithology) A group of common grackles.

(transitive) To harass, pester or annoy someone persistently or incessantly.

(transitive) To afflict with a disease or other calamity.