(uncountable) A material or substance that is the basic structural component of the universe, typically having mass and volume, and can be made up of normal particles, not antiparticles; it can also refer to a kind of substance, printed material, especially in books or magazines, and in philosophy, it represents undeveloped potentiality subject to change and development, receiving form and becoming substance.

An affair, condition, or subject, especially one of concern or (especially when preceded by the) one that is problematic.

An approximate amount or extent.

(countable, law) Legal services provided by a lawyer or firm to their client in relation to a particular issue.

(intransitive, stative) To be important.

(transitive, in negative constructions, now England regional, Caribbean) To care about, to mind; to find important.