The systematic and deliberate destruction of a group of people, typically by killing substantial numbers of them, on the basis of their ethnicity, religion, or nationality.

(by extension) The systematic killing of substantial numbers of people on other grounds.

(by extension) The systematic suppression of ideas or practices on the basis of cultural or ethnic origin; culturicide.

(video games, roguelikes) The elimination of an entire class of monsters by the player.

(transitive) To commit genocide (against); to eliminate (a group of people) completely.