(transitive, intransitive) To damage beyond use or repair.

(transitive) To neutralize, undo a property or condition.

(transitive) To put down or euthanize.

(transitive) To severely disrupt the well-being of (a person); ruin.

(transitive, informal) To utterly defeat; to crush.

(transitive, computing) To remove data.

(transitive, bodybuilding, slang, antiphrasis) To exhaust completely and thus recreate or build up.

(transitive, slang, vulgar) To penetrate sexually in an aggressive way.

(transitive, US, slang) To sing a song extremely poorly.