An isolated thickening of tissue, especially a stiff protuberance on the lip of an orchid.

Bony tissue that forms during the healing process of a fractured bone, providing support and stability as the bone heals.

A thickened or hardened area of skin, typically on the sole of the foot, caused by repeated pressure or friction.

To develop hardened or thickened areas of skin in response to repeated pressure or friction, typically as a protective mechanism.

To form a toughened area of skin in response to pressure or friction, typically on the hands or feet.