An uneven patch of color or discoloration.

An irregularly shaped area.

(figurative) Imperfection; blemish on one’s reputation, stain.

Any of various crop diseases that cause the plant to form spots.

A bright or dark spot on old film caused by dirt and loss of the gelatin covering the film, due to age and poor film quality.

A dark spot on the skin; a pustule.

(slang) Blotting paper.

(transitive) To mark with blotches.

(intransitive) To develop blotches, to become blotchy.