(literary, archaic) A feeling of discomfort or vexation caused by what one dislikes.

(literary, archaic) That which causes such a feeling.

(transitive) To disturb or irritate, especially by continued or repeated acts; to bother with unpleasant deeds.

(intransitive) To do something to upset or anger someone; to be troublesome.

(transitive) To molest; to harm; to injure.